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KMID : 1007520160250010349
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Food Science and Biotechnology
2016 Volume.25 No. 1 p.349 ~ p.353
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Red Bean Extracts Protect Rats against Intestinal Inflammatory Damage
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Choi Ki-Choon
Cho Seong-Wan
Lee Jeong-Chae
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Abstract
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Red beans comprise part of the diet in Korean culture. Anti-inflammatory and anti-septic activities of the butanol fraction of red bean ethanol extracts (BF-RBEE) are known. The intestinal antiinflammatory activity of BF-RBEE and related mechanisms were studied using a rat model of acetic acid-induced colitis. Oral treatment with BF-RBEE (100 mg/kg of body weight) suppressed body weight loss and intestinal inflammatory damage in colitic rats. BF-RBEE treatment reduced the myeloperoxidase activity and the malondialdehyde level that were increased in colitic rats, and restored the reduced level of glutathione. BF-RBEE also inhibited acetic acid-mediated increases in mRNA levels of nitric oxide synthase, interleukin-1β, and tumor necrosis factor-α. Similarly, treatment with 1mg/kg of prednisolone protected rats against intestinal colitic damage with corresponding decreases in levels of these inflammatory indicators. Red beans can be useful for treatment of intestinal inflammatory diseases.
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KEYWORD
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red bean, colitis, intestinal damage, inflammatory cytokine, anti-inflammation
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